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Acute HIV infection presenting as erythema multiforme in a 45-year-old heterosexual man


A 45-year-old heterosexual man of European descent presented to our hospital with a 3-day history of fever, myalgia, headache and a macular papular rash. The rash originated on his left shoulder and anterior chest wall before extending to chest, back and abdomen. The rash also involved the palmar aspect of his hands and the plantar aspect of his feet.

Learning Outcomes

HIV should be considered in all patients presenting with a new rash.

Acute HIV infection can present as febrile illness associated with any rash, including erythema multiforme.

A detailed sexual history should be obtained when a patient presents with a new generalised rash.

Medical Journal of Australia
Reading: Journal; textbook; book
0h : 30m
MBA: 0h : 30m
ACRRM - Fellow: 0.5 pts
ACRRM - Non Fellow: 0.5 pts
RACGP: 1 pt
CICM: 0.5 pts
RACP: 0.5 pts
Infectious diseases and parasitology

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